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Available Trials

Help us find a new medication to treat or even cure your medical condition!

 

Currently Enrolling Trials

Dermatology
[fa icon="plus-square-o"] Acne

Acne is one of the most common skin conditions in the United States affecting both men and women of all ages. Acne is a chronic inflammatory skin condition that occurs when hair follicles plug with oil and dead skin cells. There are many different types of prescription, herbal, and home remedies that are designed to treat the signs and symptoms of acne. However, not one treatment can cure acne.

Clinical research is paving the way to identify new types of acne treatments that have fewer side effects and are more effective in shorter amount of time. PRG and our board certified dermatologists are working together with leading pharmaceutical companies to conduct research on new topical and oral acne medications. To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

[fa icon="plus-square-o"] Actinic Keratosis (Pre-cancerous Skin Lesions)

Actinic Keratosis (AK) is a very common type of skin condition that is also referred to as a pre-cancerous skin lesion. AK’s are very common in patients with fair skin or that reside in sunny areas. AK’s are characterized by a rough or scaly patch on the skin that is caused typically by years of sun exposure.

 

AK’s typically occur on skin that is exposed to the sun, for example the face and scalp. AK’s are traditionally treated by a dermatologist with either a topical medication or a procedure called cryo-freezing. Even though, there are multiple prescription topical medications on the market there is still a need to identify one that has reduced side effects with better results.

 

Clinical research is paving the way to identify new types of treatments for AK that have fewer side effects and are more effective in a shorter amount of time. PRG and our board-certified dermatologists are working together with leading pharmaceutical companies to conduct research on a new topical medication for AK. To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

[fa icon="plus-square-o"] Melanoma

Melanoma is a malignant tumor that starts in melanocytes. Melanocytes are a type of cell that make melanin, which is the pigment that gives your skin and eyes their color. Malignant means that it can spread, or metastasize, to other parts of the body. The exact cause of all melanomas isn't clear, but exposure to ultraviolet (UV) radiation from sunlight or tanning lamps and beds increases your risk of developing melanoma.

Treatment options for patients with melanoma range from surgery to chemo or radiation therapy to a combination. There is ongoing research to identify the sole cause of melanoma as well as to design more effective and safer treatment options to patients. One theory of thought is developing a melanoma vaccination. PRG and our board certified dermatologists are involved with research at a potential melanoma vaccine for patients who have already had melanoma. To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

[fa icon="plus-square-o"] Psoriasis

Psoriasis is a chronic disease that develops when a person’s immune system sends faulty signals to the skin cells telling them to grow too quickly. New skin cells grow in days instead of weeks. The body does not shed these excess skin cells. These skin cells pile up on the surface of the skin, causing patches of psoriasis to form. There is no cure for Psoriasis only treatments for the symptoms.

Clinical research is ongoing to identify new treatments and a possible cure. PRG and our board certified dermatologists are working with pharmaceutical companies, researching new topical and FDA approved biological medications designed to treat the symptoms of psoriasis. To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

[fa icon="plus-square-o"] Warts

Common Warts occur in individuals commonly. Common warts are small, grainy skin growths that occur most often on your fingers or hands. They can be rough to the touch and often feature a pattern of tiny black dots.

There are various treatments for common warts including, medications, freezing and/or burning of the warts. However, no one treatment alone is a gurantee to treat one or multiple warts. PRG has teamed up with a leading dermatology focused pharmaceutical company a local established dermatology practice to research a new topical medication that aims to clear and prevent future warts. To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

Orthopedics
[fa icon="plus-square-o"] Articular Cartilage Injury (Knee Ligament Study)

Articular Cartilage Injury (ACI), is used to describe damage to a type of cartilage in the knee. The ends of the three bones in the knee joint are covered with what is know as articular cartilage, a tough, elastic material that helps absorb shock and allows the knee joint to move smoothly.

ACI’s occur most often in young adults and can be caused by injury (trauma), overuse, parts out of alignment, or muscle weakness. Instead of gliding smoothly across the lower end of the thigh bone, the knee cap rubs against it, thereby roughening the cartilage underneath the knee cap.

The most frequent symptom of an ACI is a dull pain around or under the knee cap that worsens when walking down stairs or hills. A person may also feel pain when climbing stairs or when the knee bears weight as it straightens. The disorder is common in runners and is also seen in skiers, cyclists, and soccer players.

A difficult challenge for orthopedic surgeons is the treatment of injured joint surface cartilage in the young and active patient. Localized damage to one of the surfaces of the knee joint can lead to degradation and destruction of the opposing healthy joint surface. Total knee replacement is an excellent option in the older patient, but for young active patients who are not candidates for knee replacement we must find a way to get healing of these injured surfaces with healthy hyaline cartilage to avoid long-term problems with degenerative arthritis. Traditional treatments have focused on stimulating the bone at the base of a full thickness cartilage defect by drilling, burring, or microfracturing with a special pick. These treatments cause bleeding and healing with fibrocartilage or "scar cartilage" which is not as resilient as normal hyaline cartilage. These treatments remain the first line of treatment for isolated lesions of articular cartilage in the knee.

Research is a key component in identifying new treatment pathways to alleviate the potential of long-term problems that can be associated with the microfracturing procedure. PRG is engaging with a local group of orthopedic surgeons to test the safety and effectiveness of a novel treatment therapy for patients with qualifying ACI’s with the aim of providing patients with optimal long-term outcomes. To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

[fa icon="plus-square-o"] Knee Replacement Study

PRG is working with a leading orthopedic group, OrthoArizona, looking at a new pain medication for patients undergoing a total knee replacement surgery.

Knee replacements are a very common procedure and are indicated for a variety of different reasons. Most knee replacement surgeries require patients to be on a post-operative pain medication regimen. PRG is currently working with leading physicians at OrthoArizona to identify a new type of pain medication that is provided to the patient during the operation.

For the trial the pharmaceutical company is covering the cost of the entire knee replacement procedure for the patient. To learn more about the trial and to see if you might be a candidate complete the form on the right or call us at 480-889-1211.

[fa icon="plus-square-o"] Spinal Fusion Study

PRG is working with a leading orthopedic spine surgeon looking at a Food and Drug Administration (FDA) approved medication to reduce the post-operative pain that is associated with patients undergoing one or two level spinal fusions.

Spinal fusions are very common procedures for patients who have chronic back pain associated with an underlying medical condition. Spinal fusions can be very painful and the goal of this clinical trial is to potential identify a new type of treatment that lessens the pain after spinal fusions. To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

Podiatry
[fa icon="plus-square-o"] Bunions

A bunion is a very common condition of the foot where a bony “bump” forms on the joint at the base of the big toe. Bunions may or may not be painful but can cause putting on a shoe or finding a shoe that fits difficult.

 There is no one underlying cause of bunions. However, many theorize that the development of a bunion can be related to wearing tight shoes, foot stress, and arthritis as well as other conditions.

 There are a variety of treatments both non-surgical and surgical. A surgical approach is most often the best solution for patients who experience painful bunions or those who see their bunion(s) as unsightly and want them removed. PRG is working with a leading orthopedic foot and ankle practice to research a new type of post-operative pain medication for patients undergoing bunion removal surgery. The medication is non-narcotic. Patients who qualify for the study will receive bunion removal surgery and post-operative care for 72 hours at no cost. In addition, patients may be compensated for their time and travel during the study. To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

[fa icon="plus-square-o"] Diabetic Foot Ulcer

A diabetic foot ulcer or DFU is an open sore most often located anywhere on the bottom of your foot but can occur on the top of the foot or near the ankle. DFU's occur in patients who have been diagnosed previously with Diabetes Type I or II. DFU's commonly occur because diabetes can reduce blood flow to your feet and cause a loss of feeling or numbness. This can mean that foot injuries do not heal well, and you may not notice if your foot is sore or injured leading to a hard-to-heal wound. 

There are various treatments options for patients with a DFU. These treatments can range from surgical procedures, compression therapy, skin or substitute skin grafts to topical medications. However, not all treatments are effective for all individuals and most often then not the time to heal is months not days. clinical Research in innovating the way to identify a potential safe and effective treatment for all patients with a DFU. PRG and our podiatrists are dedicated to providing alternative, novel treatment options to our patients to potentially provide a treatment to heal their DFU(s). To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

[fa icon="plus-square-o"] Toe Nail Fungus

Toenail fungus or the medical term Onychomycosis is a very common condition of the toenails. The most common sign or symptom is the toenail(s) becoming thick or discolored: white, black, yellow, or green. As the infection worsens the nail(s) can become brittle and break off in little pieces. 

Toenail fungus is believed to be one, if not the most, common type of foot issue. Luckily, there are two main types of prescription medications and multiple over-the-counter and home remedies available to treat the toenail fungus. However, toenail fungus is very difficult to treat as the toenail can take up to a year to grown out completely. Even with all of the treatment options available, there is not one that works all the time. 

PRG and our podiatrists are propelling the future treatment of toenail fungus through a novel treatment that requires no daily topical or oral treatment. To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

Fertility and Women's Health
[fa icon="plus-square-o"] Absent Periods - Hypo Hypo

We are currently looking for patients who have absent (no) menstrual cycles and are looking to conceive.

A medical condition called Primary Hypogonadotropic hypogonadism (HH) is a disorder in where the body does not secrete any or enough of certain hormones that are associated with the ovaries which include, gonadotropin-releasing hormone (GnRH), follicle stimulating hormone (FSH), and luteinizing hormone (LH).

Normally, the hypothalamus in the brain releases gonadotropin-releasing hormone (GnRH), which stimulates the pituitary gland to release follicle stimulating hormone (FSH) and luteinizing hormone (LH). These hormones tell the ovaries to release additional hormones that lead to normal sexual development in puberty.

In HH patients, the normal pathway, described above, is interrupted causing a lack of hormones that contribute to normal sexual development. There is no one known cause for HH and can be related or associated with damage to the pituitary gland, to genetics, to high stress levels.

The most common symptom is loss of menstrual cycles in women, thus becoming a preventative in the ability to conceive.

Current treatments mostly include the use of hormones either taken orally or as injections.

To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

[fa icon="plus-square-o"] Endometriosis
A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials and observational studies. PRG participates in both clinical trial and observational studies.
Psychiatry
[fa icon="plus-square-o"] Post-Partum Depression

Post-Partum Depression, or PPD, is a very common type of depression that occurs prior or after the birth of a child. The severity of PPD varies from person to person and typically resolves within a few months when properly treated.

 

Some common symptoms of PPD are; insomnia, loss of appetite, intense irritability, and difficulty bonding with the baby. It is important to note that these are common symptoms and are not solely used to diagnosis PPD.

 

There are many types of treatments for patients dealing with PPD. They can include; counseling, antidepressants, or hormone therapies. However, there is not one type of medication that works for everyone. For this very reason, a tremendous amount of research is going into finding a therapy that helps anyone dealing with moderate to severe type PPD. PRG is conducting a clinical trial where we are looking for patients who are dealing with PPD. To learn more about this opportunity give us a call at 480-889-1211 or complete our study inquiry form to the right. This study is being conducted by a licensed and board-certified psychiatrist. There is no cost to you or your medical insurance. Compensation is also available for patients who qualify for the trial. 

Pain
[fa icon="plus-square-o"] Chronic Low Back Pain

Chronic Low Back Pain (CLBP) affects millions of individuals. CLBP can be contributed to a number of cause ranging from genetics to trauma. The most common medication treatment for CLBP is narcotics. With most types of medication, you are treating the symptom not necessarily the true cause of the pain.

PRG is collaborating with a leading pharmaceutical company and renowned board-certified anesthesiologist and pain management physician to research a new procedure to potential repair damaged discs in the back that can be contributed to causing CLBP. To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

[fa icon="plus-square-o"] Post-operative Pain Device

PRG is working with a leading device company to research their device further and how it helps with pain after surgical procedures.

Post-operative pain both acute, meaning right after surgery, and chronic – a consistent pain that has originated from having a surgical procedure are typically treated with some type of oral or injectable medications. Research on how to reduce oral pain medications for individuals dealing with acute and chronic pain due to a surgical procedure continues to grow. One reason to why research in this area is so important is due to the potential side effects that can occur from taking narcotic medications.

To learn more about the trial and to see if you might be a candidate complete the form on the right or call us at 480-889-1211.

Complete this form to obtain addtional information on one of our trials or call us at    480 - 889 - 1211