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Help us find a new medication for treatment or even a cure! 

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Currently Enrolling Trials

Orthopedics
[fa icon="plus-square-o"] Articular Cartilage Injury

Articular Cartilage Injury (ACI), is used to describe damage to a type of cartilage in the knee. The ends of the three bones in the knee joint are covered with what is know as articular cartilage, a tough, elastic material that helps absorb shock and allows the knee joint to move smoothly.

ACI’s occur most often in young adults and can be caused by injury (trauma), overuse, parts out of alignment, or muscle weakness. Instead of gliding smoothly across the lower end of the thigh bone, the knee cap rubs against it, thereby roughening the cartilage underneath the knee cap.

The most frequent symptom of an ACI is a dull pain around or under the knee cap that worsens when walking down stairs or hills. A person may also feel pain when climbing stairs or when the knee bears weight as it straightens. The disorder is common in runners and is also seen in skiers, cyclists, and soccer players.

A difficult challenge for orthopedic surgeons is the treatment of injured joint surface cartilage in the young and active patient. Localized damage to one of the surfaces of the knee joint can lead to degradation and destruction of the opposing healthy joint surface. Total knee replacement is an excellent option in the older patient, but for young active patients who are not candidates for knee replacement we must find a way to get healing of these injured surfaces with healthy hyaline cartilage to avoid long-term problems with degenerative arthritis. Traditional treatments have focused on stimulating the bone at the base of a full thickness cartilage defect by drilling, burring, or microfracturing with a special pick. These treatments cause bleeding and healing with fibrocartilage or "scar cartilage" which is not as resilient as normal hyaline cartilage. These treatments remain the first line of treatment for isolated lesions of articular cartilage in the knee.

Research is a key component in identifying new treatment pathways to alleviate the potential of long-term problems that can be associated with the microfracturing procedure. PRG is engaging with a local group of orthopedic surgeons to test the safety and effectiveness of a novel treatment therapy for patients with qualifying ACI’s with the aim of providing patients with optimal long-term outcomes. To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

[fa icon="plus-square-o"] Knee Replacement Study

PRG is working with a leading orthopedic group, OrthoArizona, looking at a new pain medication for patients undergoing a total knee replacement surgery.

Knee replacements are a very common procedure and are indicated for a variety of different reasons. Most knee replacement surgeries require patients to be on a post-operative pain medication regimen. PRG is currently working with leading physicians at OrthoArizona to identify a new type of pain medication that is provided to the patient during the operation.

For the trial the pharmaceutical company is covering the cost of the entire knee replacement procedure for the patient. To learn more about the trial and to see if you might be a candidate complete the form on the right or call us at 480-889-1211.

Podiatry
[fa icon="plus-square-o"] Diabetic Foot Ulcer

A diabetic foot ulcer or DFU is an open sore most often located anywhere on the bottom of your foot but can occur on the top of the foot or near the ankle. DFU's occur in patients who have been diagnosed previously with Diabetes Type I or II. DFU's commonly occur because diabetes can reduce blood flow to your feet and cause a loss of feeling or numbness. This can mean that foot injuries do not heal well, and you may not notice if your foot is sore or injured leading to a hard-to-heal wound. 

There are various treatments options for patients with a DFU. These treatments can range from surgical procedures, compression therapy, skin or substitute skin grafts to topical medications. However, not all treatments are effective for all individuals and most often then not the time to heal is months not days. clinical Research in innovating the way to identify a potential safe and effective treatment for all patients with a DFU. PRG and our podiatrists are dedicated to providing alternative, novel treatment options to our patients to potentially provide a treatment to heal their DFU(s). To learn more about becoming a participant complete the form on the right or call us at 480-889-1211.

Complete this form to obtain addtional information on one of our trials or call us at    480-889-1211 

OrthoArizona Clinical Trials